Poke root has many benefits and has been used by Native Americans for a plethora of conditions including a heart stimulant, for rheumatism, arthritis, dysentery, and cancer. The plant contains a protein called “pokeweed antiviral protein,” or PAP for short that may have anti-tumor effects. It is currently being studied for its anti-cancer properties, and some studies have shown that certain formulations of PAP may be useful against some types of cancer cells that depend on hormones to grow such as breast, ovarian, and prostate cancer. The plant may have certain properties that both help strengthen the immune system by interacting with the proliferating T-cells and by inhibiting production of HIV viral proteins, Poke root also is used to alleviate headaches, hemorrhoids, arthritis, aches and pains. The berries of the plant is used to make dye. and the leaves has been used to make poke salad.